The implantation of the MONOSORB monofilament synthetic absorbable surgical suture elicits a minimal inflammatory reaction which is followed by the development of fibrous connective tissue in place.

Progressive loss of tensile strength and eventual absorption of the suture occurs by means of hydrolysis, where the polymer degrades to carbon dioxide and water which is subsequently absorbed and metabolized by the tissues. Absorption begins as a loss of tensile strength without appreciable loss of mass. The retention of the MONOSORB absorbable suture is 65-70% of the original tensile strength after 4 weeks and 50-60% after 6 weeks. The absorption of the suture is essentially completed after a period of 180-220 days.